diff --git a/docs/CHANGELOG.md b/docs/CHANGELOG.md
index 14cb63bc7..b11a80d48 100644
--- a/docs/CHANGELOG.md
+++ b/docs/CHANGELOG.md
@@ -13,6 +13,7 @@ The following `tip` changes can be tested by building VictoriaMetrics components
 
 * BUGFIX: properly return errors from [export APIs](https://docs.victoriametrics.com/#how-to-export-time-series). Previously these errors were silently suppressed. See [this pull request](https://github.com/VictoriaMetrics/VictoriaMetrics/pull/5649).
 * BUGFIX: [vmagent](https://docs.victoriametrics.com/vmagent.html): properly discover targets for `role: endpoints` and `role: endpointslice` in [kubernetes_sd_configs](https://docs.victoriametrics.com/sd_configs.html#kubernetes_sd_configs). Previously some `endpoints` and `endpointslice` targets could be left undiscovered or some targets could have missing `__meta_*` labels when performing service discovery in busy Kubernetes clusters with large number of pods. See [this pull request](https://github.com/VictoriaMetrics/VictoriaMetrics/pull/5557).
+* BUGFIX: [vmagent](https://docs.victoriametrics.com/vmagent.html): respect explicitly set `series_limit: 0` in [scrape_config](https://docs.victoriametrics.com/sd_configs.html#scrape_configs). This allows removing [`series_limit` restriction](https://docs.victoriametrics.com/vmagent.html#cardinality-limiter) on a per-`scrape_config` basis when global limit is set via `-promscrape.seriesLimitPerTarget`. Previously, `0` value was ignored in favor of `-promscrape.seriesLimitPerTarget`.
 * BUGFIX: [MetricsQL](https://docs.victoriametrics.com/MetricsQL.html): properly process queries with too big lookbehind window such as `foo[100y]`. Previously, such queries could return empty responses even if `foo` is present in database. See [this issue](https://github.com/VictoriaMetrics/VictoriaMetrics/issues/5553).
 * BUGFIX: [MetricsQL](https://docs.victoriametrics.com/MetricsQL.html): properly handle possible negative results caused by float operations precision error in rollup functions like rate() or increase(). See [this issue](https://github.com/VictoriaMetrics/VictoriaMetrics/issues/5571).
 
diff --git a/lib/promscrape/config.go b/lib/promscrape/config.go
index 5cf006c00..8b33773f7 100644
--- a/lib/promscrape/config.go
+++ b/lib/promscrape/config.go
@@ -283,7 +283,7 @@ type ScrapeConfig struct {
 	StreamParse         bool                       `yaml:"stream_parse,omitempty"`
 	ScrapeAlignInterval *promutils.Duration        `yaml:"scrape_align_interval,omitempty"`
 	ScrapeOffset        *promutils.Duration        `yaml:"scrape_offset,omitempty"`
-	SeriesLimit         int                        `yaml:"series_limit,omitempty"`
+	SeriesLimit         *int                       `yaml:"series_limit,omitempty"`
 	NoStaleMarkers      *bool                      `yaml:"no_stale_markers,omitempty"`
 	ProxyClientConfig   promauth.ProxyClientConfig `yaml:",inline"`
 
@@ -1028,8 +1028,8 @@ func getScrapeWorkConfig(sc *ScrapeConfig, baseDir string, globalCfg *GlobalConf
 		noStaleTracking = *sc.NoStaleMarkers
 	}
 	seriesLimit := *seriesLimitPerTarget
-	if sc.SeriesLimit > 0 {
-		seriesLimit = sc.SeriesLimit
+	if sc.SeriesLimit != nil {
+		seriesLimit = *sc.SeriesLimit
 	}
 	swc := &scrapeWorkConfig{
 		scrapeInterval:       scrapeInterval,
diff --git a/lib/promscrape/config_test.go b/lib/promscrape/config_test.go
index 7fe042b5f..a5524b429 100644
--- a/lib/promscrape/config_test.go
+++ b/lib/promscrape/config_test.go
@@ -1289,6 +1289,29 @@ scrape_configs:
 			jobNameOriginal: "foo",
 		},
 	})
+
+	defaultSeriesLimitPerTarget := *seriesLimitPerTarget
+	*seriesLimitPerTarget = 1e3
+	f(`
+scrape_configs:
+- job_name: foo
+  series_limit: 0
+  static_configs:
+  - targets: ["foo.bar:1234"]
+`, []*ScrapeWork{
+		{
+			ScrapeURL:       "http://foo.bar:1234/metrics",
+			ScrapeInterval:  defaultScrapeInterval,
+			ScrapeTimeout:   defaultScrapeTimeout,
+			jobNameOriginal: "foo",
+			Labels: promutils.NewLabelsFromMap(map[string]string{
+				"instance": "foo.bar:1234",
+				"job":      "foo",
+			}),
+			SeriesLimit: 0,
+		},
+	})
+	*seriesLimitPerTarget = defaultSeriesLimitPerTarget
 }
 
 func equalStaticConfigForScrapeWorks(a, b []*ScrapeWork) bool {