diff --git a/src/input_common/drivers/mouse.cpp b/src/input_common/drivers/mouse.cpp
index e92ea878f9..dac29c78f3 100644
--- a/src/input_common/drivers/mouse.cpp
+++ b/src/input_common/drivers/mouse.cpp
@@ -85,7 +85,7 @@ void Mouse::UpdateThread(std::stop_token stop_token) {
 }
 
 void Mouse::UpdateStickInput() {
-    if (!Settings::values.mouse_panning) {
+    if (!IsMousePanningEnabled()) {
         return;
     }
 
@@ -111,8 +111,8 @@ void Mouse::UpdateStickInput() {
 }
 
 void Mouse::UpdateMotionInput() {
-    const float sensitivity = Settings::values.mouse_panning ? default_motion_panning_sensitivity
-                                                             : default_motion_sensitivity;
+    const float sensitivity =
+        IsMousePanningEnabled() ? default_motion_panning_sensitivity : default_motion_sensitivity;
 
     const float rotation_velocity = std::sqrt(last_motion_change.x * last_motion_change.x +
                                               last_motion_change.y * last_motion_change.y);
@@ -134,7 +134,7 @@ void Mouse::UpdateMotionInput() {
         .delta_timestamp = update_time * 1000,
     };
 
-    if (Settings::values.mouse_panning) {
+    if (IsMousePanningEnabled()) {
         last_motion_change.x = 0;
         last_motion_change.y = 0;
     }
@@ -144,7 +144,7 @@ void Mouse::UpdateMotionInput() {
 }
 
 void Mouse::Move(int x, int y, int center_x, int center_y) {
-    if (Settings::values.mouse_panning) {
+    if (IsMousePanningEnabled()) {
         const auto mouse_change =
             (Common::MakeVec(x, y) - Common::MakeVec(center_x, center_y)).Cast<float>();
         const float x_sensitivity =
@@ -219,7 +219,7 @@ void Mouse::ReleaseButton(MouseButton button) {
     SetButton(real_mouse_identifier, static_cast<int>(button), false);
     SetButton(touch_identifier, static_cast<int>(button), false);
 
-    if (!Settings::values.mouse_panning) {
+    if (!IsMousePanningEnabled()) {
         SetAxis(identifier, mouse_axis_x, 0);
         SetAxis(identifier, mouse_axis_y, 0);
     }
@@ -243,6 +243,11 @@ void Mouse::ReleaseAllButtons() {
     button_pressed = false;
 }
 
+bool Mouse::IsMousePanningEnabled() {
+    // Disable mouse panning when a real mouse is connected
+    return Settings::values.mouse_panning && !Settings::values.mouse_enabled;
+}
+
 std::vector<Common::ParamPackage> Mouse::GetInputDevices() const {
     std::vector<Common::ParamPackage> devices;
     devices.emplace_back(Common::ParamPackage{
diff --git a/src/input_common/drivers/mouse.h b/src/input_common/drivers/mouse.h
index 0e8edcce15..2b93a40b9c 100644
--- a/src/input_common/drivers/mouse.h
+++ b/src/input_common/drivers/mouse.h
@@ -99,6 +99,8 @@ private:
     void UpdateStickInput();
     void UpdateMotionInput();
 
+    bool IsMousePanningEnabled();
+
     Common::Input::ButtonNames GetUIButtonName(const Common::ParamPackage& params) const;
 
     Common::Vec2<int> mouse_origin;
diff --git a/src/yuzu/configuration/configure_input_player.ui b/src/yuzu/configuration/configure_input_player.ui
index 43f6c7b50b..611a794778 100644
--- a/src/yuzu/configuration/configure_input_player.ui
+++ b/src/yuzu/configuration/configure_input_player.ui
@@ -3105,21 +3105,6 @@
                     </property>
                     <item>
                      <widget class="QPushButton" name="mousePanningButton">
-                      <property name="minimumSize">
-                       <size>
-                        <width>68</width>
-                        <height>0</height>
-                       </size>
-                      </property>
-                      <property name="maximumSize">
-                       <size>
-                        <width>68</width>
-                        <height>16777215</height>
-                       </size>
-                      </property>
-                      <property name="styleSheet">
-                       <string notr="true">min-width: 68px;</string>
-                      </property>
                       <property name="text">
                        <string>Configure</string>
                       </property>
diff --git a/src/yuzu/configuration/configure_mouse_panning.cpp b/src/yuzu/configuration/configure_mouse_panning.cpp
index b3386347e2..e37c546b0c 100644
--- a/src/yuzu/configuration/configure_mouse_panning.cpp
+++ b/src/yuzu/configuration/configure_mouse_panning.cpp
@@ -2,6 +2,7 @@
 // SPDX-License-Identifier: GPL-2.0-or-later
 
 #include <QCloseEvent>
+#include <QMessageBox>
 
 #include "common/settings.h"
 #include "ui_configure_mouse_panning.h"
@@ -33,13 +34,20 @@ void ConfigureMousePanning::SetConfiguration(float right_stick_deadzone, float r
     ui->min_decay->setValue(Settings::values.mouse_panning_min_decay.GetValue());
 
     if (right_stick_deadzone > 0.0f || right_stick_range != 1.0f) {
-        ui->warning_label->setText(QString::fromStdString(
-            "Mouse panning works better with a deadzone of 0% and a range of 100%.\n"
-            "Current values are " +
-            std::to_string(static_cast<int>(right_stick_deadzone * 100.0f)) + "% and " +
-            std::to_string(static_cast<int>(right_stick_range * 100.0f)) + "% respectively."));
-    } else {
-        ui->warning_label->hide();
+        const QString right_stick_deadzone_str =
+            QString::fromStdString(std::to_string(static_cast<int>(right_stick_deadzone * 100.0f)));
+        const QString right_stick_range_str =
+            QString::fromStdString(std::to_string(static_cast<int>(right_stick_range * 100.0f)));
+
+        ui->warning_label->setText(
+            tr("Mouse panning works better with a deadzone of 0% and a range of 100%.\nCurrent "
+               "values are %1% and %2% respectively.")
+                .arg(right_stick_deadzone_str, right_stick_range_str));
+    }
+
+    if (Settings::values.mouse_enabled) {
+        ui->warning_label->setText(
+            tr("Emulated mouse is enabled. This is incompatible with mouse panning."));
     }
 }
 
@@ -69,5 +77,14 @@ void ConfigureMousePanning::ApplyConfiguration() {
     Settings::values.mouse_panning_decay_strength = static_cast<float>(ui->decay_strength->value());
     Settings::values.mouse_panning_min_decay = static_cast<float>(ui->min_decay->value());
 
+    if (Settings::values.mouse_enabled && Settings::values.mouse_panning) {
+        Settings::values.mouse_panning = false;
+        QMessageBox::critical(
+            this, tr("Emulated mouse is enabled"),
+            tr("Real mouse input and mouse panning are incompatible. Please disable the "
+               "emulated mouse in input advanced settings to allow mouse panning."));
+        return;
+    }
+
     accept();
 }
diff --git a/src/yuzu/configuration/configure_mouse_panning.ui b/src/yuzu/configuration/configure_mouse_panning.ui
index 33615be54e..84fb7ee809 100644
--- a/src/yuzu/configuration/configure_mouse_panning.ui
+++ b/src/yuzu/configuration/configure_mouse_panning.ui
@@ -9,10 +9,10 @@
    <item>
     <widget class="QCheckBox" name="enable">
      <property name="text">
-      <string>Enable</string>
+      <string>Enable mouse panning</string>
      </property>
      <property name="toolTip">
-      <string>Can be toggled via a hotkey</string>
+      <string>Can be toggled via a hotkey. Default hotkey is Ctrl + F9</string>
      </property>
     </widget>
    </item>